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Aspirin is absorbed rapidly from the stomach and intestine by passive diffusion. Aspirin is a prodrug, which is transformed into salicylate in the stomach, in the intestinal mucosa, in the blood and mainly in the liver.
Is aspirin absorbed more in stomach or intestine?
At pH 3.5 or 6.5, intestinal absorption of aspirin was greater than gastric absorption of the compound. Aspirin was not absorbed by the stomach at pH 6.5. These experiments indicate that aspirin can be absorbed to an appreciable extent in its ionized form by the small intestine but not by the stomach.
How is aspirin absorbed in the small intestine?
At higher pH, in the intestine (pH = 6), a greater proportion of aspirin is ionized, so it moves across membranes more slowly (however, due to the very large surface area for absorption in the intestine, all the aspirin does enter the bloodstream).
What can affect the absorption of aspirin?
Three gastrointestinal factors influencing aspirin absorption have been selectively adjusted for quantitative measurement of their effect on the rate of salicylate absorption in humans and dogs. These are (a) gastric emptying, (b) aspirin dissolution rate, and (c) intragastric pH.
How is aspirin metabolised and excreted?
Aspirin undergoes phase 1 hydrolysis to salicylic acid. In phase 2 it is congugated with either glycine or glucoronic acid forming a range of ionised metabolytes that can then be excreted in the urine.
Where is aspirin mostly absorbed?
However, aspirin and couple other weak organic acids don't follow normal kinetics across lipid membranes: in fact, most absorption occurs in the small intestine, because the surface area is larger and membranes are more permeable (the general explanation has to do with micoenvironments at the surface of the enterocytes …
Which part of the body absorbs aspirin?
Aspirins absorption is pH sensitive at the level of the small intestine. Absorption is higher through the small intestine than the stomach for the same pH range.
Where is aspirin mainly absorbed?
Aspirin is absorbed rapidly from the stomach and intestine by passive diffusion. Aspirin is a prodrug, which is transformed into salicylate in the stomach, in the intestinal mucosa, in the blood and mainly in the liver.
Where is aspirin absorbed?
Absorption is higher through the small intestine than the stomach for the same pH range. At pH 3.5 or 6.5, aspirin's intestinal absorption is greater than the gastric absorption of the compound. The stomach does not absorb aspirin at pH 6.5.
How is aspirin broken down in the body?
Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin.
