266 065 921 7a2 5eb 87f b15 f35 e10 d0b 802 4ec faa 07b 67c 792 331 59a 681 324 1b0 338 c4a 5dd 865 a70 b37 02b bc2 c76 496 5b0 601 9c3 a0d 019 69e 8cc 61d 2f5 c06 93f 08a 41f a43 97a 665 e06 979 f88 ade 2f2 a07 a71 fde a45 090 7fb 85a 387 817 01d 119 28a 2a6 31c 82e 437 bb2 708 390 4b0 96e 72c 8ec 026 f33 1d9 933 054 6c3 520 ed2 5f1 4dc b61 359 6d7 0d2 4e2 124 a20 80d 9d1 9ea 20d 45a bb6 98a 17d
Aspirin is absorbed rapidly from the stomach and intestine by passive diffusion. Aspirin is a prodrug, which is transformed into salicylate in the stomach, in the intestinal mucosa, in the blood and mainly in the liver.
Is aspirin absorbed more in stomach or intestine?
At pH 3.5 or 6.5, intestinal absorption of aspirin was greater than gastric absorption of the compound. Aspirin was not absorbed by the stomach at pH 6.5. These experiments indicate that aspirin can be absorbed to an appreciable extent in its ionized form by the small intestine but not by the stomach.
How is aspirin absorbed in the small intestine?
At higher pH, in the intestine (pH = 6), a greater proportion of aspirin is ionized, so it moves across membranes more slowly (however, due to the very large surface area for absorption in the intestine, all the aspirin does enter the bloodstream).
What can affect the absorption of aspirin?
Three gastrointestinal factors influencing aspirin absorption have been selectively adjusted for quantitative measurement of their effect on the rate of salicylate absorption in humans and dogs. These are (a) gastric emptying, (b) aspirin dissolution rate, and (c) intragastric pH.
How is aspirin metabolised and excreted?
Aspirin undergoes phase 1 hydrolysis to salicylic acid. In phase 2 it is congugated with either glycine or glucoronic acid forming a range of ionised metabolytes that can then be excreted in the urine.
Where is aspirin mostly absorbed?
However, aspirin and couple other weak organic acids don't follow normal kinetics across lipid membranes: in fact, most absorption occurs in the small intestine, because the surface area is larger and membranes are more permeable (the general explanation has to do with micoenvironments at the surface of the enterocytes …
Which part of the body absorbs aspirin?
Aspirins absorption is pH sensitive at the level of the small intestine. Absorption is higher through the small intestine than the stomach for the same pH range.
Where is aspirin mainly absorbed?
Aspirin is absorbed rapidly from the stomach and intestine by passive diffusion. Aspirin is a prodrug, which is transformed into salicylate in the stomach, in the intestinal mucosa, in the blood and mainly in the liver.
Where is aspirin absorbed?
Absorption is higher through the small intestine than the stomach for the same pH range. At pH 3.5 or 6.5, aspirin's intestinal absorption is greater than the gastric absorption of the compound. The stomach does not absorb aspirin at pH 6.5.
How is aspirin broken down in the body?
Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin.
