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7. “Drug concentration” is derived by collecting a blood sample at any time after drug administration and measuring the amount of a drug in a given volume of blood plasma of the sample. 8. The measured drug concentration is generally known as “plasma concentration.”Jun 7, 2019
Why is plasma drug concentration important?
Plasma concentration monitoring of most antiarrhythmic agents is of value for certain specific purposes: to determine compliance to antiarrhythmic therapy, to detect and analyze possible drug interactions, to assess the benefit to risk ratio for increasing the dose of a particular antiarrhythmic agent, to maintain a …
What is drug concentration?
Drug concentration in the compartment is. defined as the amount of drug in a given volume, such. as mg/L: 1-1. Volume of distribution (V) is an important indicator of the extent of drug distribution into body fluids and tis- sues.
How is the plasma concentration of a drug determined?
When measuring the drug concentration in plasma, a sample of whole blood is drawn from the patient (like cylinder on the left). The sample is then centrifuged to separate the RBC and plasma (like the cylinder on the right). The plasma is withdrawn and analyzed for drug concentration and the RBC is discarded.
Why is plasma or serum drug concentration monitored?
Introduction. The monitoring of therapeutic drugs involves measuring drug concentrations in plasma, serum or blood. This information is used to individualise dosage so that drug concentrations can be maintained within a target range.
What happens when plasma concentration increases?
Subsequent higher doses increased sedation, all pressures, and calculated vascular resistance, and resulted in significant decreases in heart rate, cardiac output, and stroke volume.
What does peak plasma concentration mean?
peak plasma drug concentration. (Science: pharmacology) The highest level of drug that can be obtained in the blood usually following multiple doses.
Is serum concentration the same as plasma concentration?
The expression 'plasma concentration' is often used in the literature, although serum samples have been taken. In most cases serum and plasma concentrations of analytes are the same. The choice depends mostly on the policy of the hospital or the availability of the test tubes in the ward.
What is the difference between plasma and serum?
Serum is the liquid that remains after the blood has clotted. Plasma is the liquid that remains when clotting is prevented with the addition of an anticoagulant. This is not an insignificant difference.
How is plasma concentration maintained?
The therapeutic effect of most drugs is a function of the concentration at the site of drug effect, which in turn is determined by the plasma concentration. Constant plasma concentrations can be maintained by computer-controlled infusion pumps.
