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The physical principle of BNCT is a two-component system, based on the nuclear reaction that occurs when the stable isotope boron-10 is irradiated with low energy or thermal neutrons to yield highly energetic helium-4 (4He) nuclei (i.e., alpha particles) and recoiling lithium-7 (7Li) ions.
Why is boron used in neutron capture therapy?
BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. The alpha particle has a short range, therefore preferentially affecting tumor tissues while sparing more distal normal tissues.
How does BNCT work?
BNCT is emerging as a hopeful tool in treating cancer, by selectively concentrating Boron compounds in tumour cells and then subjecting the tumour cells to epithermal neutron beam radiation which selectively destroys the tumour cells.
How neutrons are used in treatment of cancer?
Neutron therapy: A neutron destroys a tumor cell through a nuclear reaction, splitting the atoms in cancerous cells into pair of different atoms which cannot recombine, and halting the tumor's growth.
What is boron used for radiation?
Because of its radiation-absorbing effect, boron is widely used in the shielding, control, and safety systems of nuclear reactors. Control rods: Boron is a primary neutron absorber used in the construction of the control rods in the core of a nuclear reactor.
What is neutron for boron?
The mass number for boron is 5; this The atomic mass of boron (symbol B) is 10.8. To determine the number of neutrons we round 10.8 to 11 and subtract the atomic number (5) and get 6; therefore, boron has 6 neutrons.
How is boron introduced to tumors?
Boron Neutron Capture Therapy (BNCT) is a non-invasive therapeutic technique for treating invasive malignant tumours. It relies on the use of neutrons for the generation of energetic alpha particles to destroy cells within the tumour, but not in the surrounding tissue.
What is neutron radiation therapy?
Fast neutron therapy is a specialized and very powerful form of external beam radiation therapy. It is often used to treat certain tumors that are radioresistant, meaning they are very difficult to kill using conventional X-ray radiation therapy.
What is radiation therapy for cancer?
Radiation therapy (also called radiotherapy) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. At low doses, radiation is used in x-rays to see inside your body, as with x-rays of your teeth or broken bones.
What is boron used for?
Boron is a mineral that is found in food and the environment. People take boron supplements as medicine. Boron is used for building strong bones, treating osteoarthritis, as an aid for building muscles and increasing testosterone levels, and for improving thinking skills and muscle coordination.
