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Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion) it is frequently considered to encompass both metabolism and excretion.Oct 10, 2021
What is the elimination phase of pharmacokinetics?
During this phase, the decline of the plasma concentration is associated solely with elimination of drug from the body, in other words it corresponds to the kinetics of drug elimination. Therefore, this phase is often called the elimination phase.
What is the difference between drug elimination and excretion?
Drug elimination is usually divided into two major components: excretion and biotransformation. Drug excretion is the removal of the intact drug. Nonvolatile drugs are excreted mainly by renal excretion, a process in which the drug passes through the kidney to the bladder and ultimately into the urine.
What is the elimination of drug from the body?
Drug excretion is the removal of drugs from the body, either as a metabolite or unchanged drug. There are many different routes of excretion, including urine, bile, sweat, saliva, tears, milk, and stool.
What is the difference between elimination and clearance?
Applied Biopharmaceutics & Pharmacokinetics (Shargel and Yu , 6th ed) defines elimination as the "irreversible removal of the drug from the body" and clearance as "volume of fluid cleared of drug per unit time".
What is the elimination phase?
The elimination phase is the phase in which you follow the low FODMAP diet strictly. The goal of this phase is to get your IBS symptoms under control and reduce them significantly.
What is distribution and elimination phase?
The early rapid decline is due to distribution to the tissue compartment, and hence this early period is called the distribution phase. Conversely, the slower decline at later times is due to drug elimination, and hence this later period is called the elimination phase.
What is the difference between elimination and secretion?
But the difference between excretion and secretion is that excretion is the removal of waste from the body, whereas secretion involves the movement of materials within the body….Excretion vs Secretion.
| Secretion | Excretion |
|---|---|
| It is an active process | It is a passive process |
•Feb 5, 2021
What is first order elimination?
Definition. First-order elimination kinetics depends on the concentration of only one reactant (drug) and a constant fraction of the drug in the body is eliminated per unit time. The rate of elimination is proportional to the amount of drug in the body. The majority of drugs are eliminated in this way.
What factors affect drug elimination?
Factors affecting renal excretion of drugs include: kidney function, protein binding, urine pH and urine flow.
